In Vitro Fertilization (IVF) is an extremely cost-effective treatment for most infertile couples, and allows us to do in the IVF lab what is not happening normally in the bedroom - no matter what the medical problem may be !
Want more information about IVF? Read the chapter on IVF in our book, How to Have a Baby.
Our equipment is state of the art and is sourced from all over the world. For example, our CO2 incubators are Nuaire incubators from USA; our stereozoom and inverted microscopes are from Olympus, Japan, and our ultrasound scanner is from Aloka, Japan. We use IVF catheters from Rocket of London, UK; ICSI pipettes from Cook, Australia; the Saturn laser unit for embryo biopsy from Research Instruments, UK ; IVF culture medium from Vitrolife, Scandinavia; and IVF disposables from Becton Dickinson, USA. Our IVF lab complies with international standards and guidelines.
Coming to Bombay (Mumbai) for IVF is extremely easy ! Bombay (Mumbai) is a major metropolis, and has its own international airport. The clinic is in the heart of south Bombay, and is an hour's ride away from the airport.
IVF treatment is done on a day-care basis, so you do not need hospitalisation at all. There are many hotels nearby. You only need to make 4 - 6 visits to the clinic during the entire fertility cycle, and after the embryo transfer, you can fly back home !
This is the protocol we use for performing IVF. The following preliminary tests, to check the quality of eggs, sperm, uterus and tubes, can be done locally with the help of your gynecologist.
- Semen analysis for husband
- Blood tests for wife ( Day 3 - FSH, LH and PRL). Specialty Ranbaxy Labs and Metropolis Labs both have a network of collection centers all over India, and are very reliable.
- HSG ( hysterosalpingogram) for wife
- Vaginal ultrasound scan for wife
Please send us these reports to confirm they are normal. The actual IVF (In Vitro Fertilization) treatment starts from Day 1 of your fertility cycle, when you start taking Inj Buserelin ( Suprefact, GnRH analog, manufactured by Hoechst) , 0.5 ml subcutaneously daily. I vial contains 6 ml and will last for 12 days. Alternative options include Lupron ( for patients from USA) or Synarel or Nasarel Spray; or Inj Decapeptyl daily.
You then need to do a vaginal ultrasound scan or E2 ( estradiol) blood level on Day 3. Specialty Ranbaxy Labs and Metropolis Labs both have a network of collection centers all over India, and are very reliable. You can do this locally in your own home town.
If the scan is normal ( no cysts in the ovaries, with a thin endometrial lining) and / or E2 level is less than 50 pg/ml, you start superovulation with HMG injections ( gonadotropins, Menogon , manufactured by Ferring ). Alternatives include other brands such as Pergonal, Metrodin, Follistim or Gonal-F. Our standard dose is 3 ampuoles ( 225 IU) IM for patients less than 35 years of age; 2 ampuoles ( 150 IU) IM for patients with PCOD; and 4 ampuoles for patients more than 35 years old.
You need to come to Bombay for a scan on Day 10; and then do alternate day scans. Your husband only needs to join you on Day 14 for a day or so ( or you can hand carry his frozen sperm sample).
This is what a typical daily schedule for an IVF cycle looks like.
- Day 1. Inj Buserelin, 0.5 ml sc. Email/ phone us you are starting
- Day 2. Inj Buserelin, 0.5 ml sc.
- Day 3. Inj Buserelin, 0.5 ml sc. Vaginal ultrasound scan and/or blood E2 level. Email/phone me with this report
- Day 4 Inj Buserelin, 0.5 ml sc. Inj Menogon ( 75 IU), 4 amp IM
- Day 5 Inj Buserelin, 0.5 ml sc. Inj Menogon ( 75 IU), 4 amp IM
- Day 6 Inj Buserelin, 0.5 ml sc. Inj Menogon ( 75 IU), 4 amp IM
- Day 7 Inj Buserelin, 0.5 ml sc. Inj Menogon ( 75 IU), 4 amp IM
- Day 8 Inj Buserelin, 0.5 ml sc. Inj Menogon ( 75 IU), 4 amp IM
- Day 9 Inj Buserelin, 0.5 ml sc. Inj Menogon ( 75 IU), 4 amp IM
- Day 10. Come to Bombay
From Day 10 onwards, patients need to continue taking daily injections, but are free to see the many delights Bombay has to offer ! You can also take a 2-day trip to lounge around the sunny beaches of Goa and/or see the famous Ajanta-Ellora caves.
We do not monitor E2 levels routinely, so you do not need daily blood tests (we don't treat our patients as pin cushions!) As a result of our simplified protocol, out of town patients can start their superovulation in their own city, and need to stay in Bombay for only 8-10 days. We also provide inexpensive accommodation facilities for patients in the clinic itself. This is especially useful when wives need to stay alone in Bombay. There are a number of hotels nearby which offer comfortable boarding and lodging as well.
You can book your tickets online, and find the best deals by asking Indian travel agents in your city. A return air ticket to India from the US costs about US $ 1000-1500. Your husband can accompany you, or you can hand-carry his frozen sperm in a dry shipper ( which you will need to borrow from your local infertility clinic). If you have failed IVF in the past, we can use advanced technology to maximise your chances of getting pregnant.