What is a normal sperm count ?
What is normal sperm motility ?
What is normal sperm morphology ?
What does the presence of pus cells in the semen signify ?
What does a normal semen analysis report mean ?
What are the reasons for a poor semen analysis report ?
What if my sperm count is zero ( azoospermia) ?
Fig 2. The anatomy of a sperm
Motility is graded from a to d, according to the World Health Organisation (WHO) Manual criteria, as follows.
Sperms of grade c and d are considered poor. If motility is poor
(this is called asthenospermia), this suggests that the testis is producing poor quality sperm and is not functioning properly - and this may mean that even the apparently motile sperm may not be able to fertilise the egg.
This is why we worry when the motility is only 20% (when it should be at least 50% ?) Many men with a low sperm count ask is - " But doctor, I just need a single sperm to fertilise my wife's egg. If my count is 10 million and motility is 20%, this means I have 2 million motile sperm in my ejaculate - why can't I get her pregnant ? " The problem is that the sperm in infertile men with a low sperm count are often not functionally competent - they cannot fertilise the egg. The fact that only 20% of the sperm are motile means that 80% are immotile - and if so many sperm (Sperm Video) cannot even swim, one worries about the functional ability of the remaining sperm. After all, if 80% of the television sets produced in a factory are defective, no one is going to buy one of the remaining 20% - even if they seem to look normal.
Putting it all together, one looks for the total number of "good" sperms in the sample - the product of the total count, the progressively motile sperm and the normally shaped sperm. This gives the progressively motile normal sperm count which is a crude index of the fertility potential of the sperm. Thus, for example, if a man has a total count of 40 million sperm per ml; of which 40% are progressively motile; and 60% are normally shaped; then his progressively motile normal sperm count is : 40 X 0.40 X 0.60 = 9.6 million sperm per ml. If the volume of the ejaculate is 3 ml, then the total motile sperm count in the entire sample is 9.6 X 3 = 28.8 million sperm.
Some labs use a computer to do the semen analysis. This is called CASA, or computer assisted semen analysis. While it may appear to be more reliable (because the test has been done "objectively" by a computer), there are still many controversies about its real value, since many of the technical details have not been standardised, and vary from lab to lab.
A normal sperm report is reassuring, and usually does not need to be repeated. If the semen analysis is normal, most doctors will not even need to examine the man, since this is then superfluous. However, remember that just because the sperm count and motility are in the normal range, this does not necessarily mean that the man is "fertile". Even if the sperm display normal motility, this does not always mean that they are capable of "working" and fertilising the egg. The only foolproof way of proving whether the sperm work is by doing IVF (in vitro fertilisation)!
Poor sperm tests can results from:
If the sperm test is abnormal, this will need to be repeated 3-4 times over a period of 3-6 months to confirm whether the abnormality is persistent or not. Don't jump to a conclusion based on just one report - remember that sperm counts do tend to vary on their own! It takes six weeks for the testes to produce new sperm - which is why you need to wait before repeating the test. It also makes sense to repeat it from another laboratory, to ensure that the report is valid.
Some men will find to their dismay that they have a zero sperm count. This is called azoospermia, and comes as a complete shock, as these men have normal libido, can ejaculate normally, and their semen looks normal .
If the report shows your sperm count is zero, please ask the laboratory to re-check it again. It's useful to request the laboratory to check two consecutive semen samples, ejaculated about 1 hour apart ( sequential semen analysis). The laboratory should be also requested to centrifuge the sample and check the pellet for sperm precursors. Some men will have occasional sperm in the pellet, which means they are not really azoospermic. This is called cryptozoospermia.
If the report is persistently zero, then the next step is to find out what the reason for the azoospermia is. There are 2 possibilities - obstructive azoospermia; or non-obstructive azoospermia. Men with obstructive azoospermia have normal testes which produce sperm normally, but whose passageway is blocked. This is usually a block at the level of the epididymis, and in these men the semen volume is normal; fructose is present; the pH is alkaline; and no sperm precursor cells are seen on semen analysis. On clinical examination, they typically have normal sized firm testes, but the epididymis is full and turgid.
Some men have obstructive azoospermia because of an absent vas deferens. Their semen volume is low ( 0.5 ml or less); the pH is acidic and the fructose is negative. The diagnosis can be confirmed by clinical examination, which shows the vas is absent. If the vas can be felt in these men, then the diagnosis is a seminal vesicle obstruction.
Men with non-obstructive azoospermia have a normal passageway, but abnormal testicular function, and their testes do not produce sperm normally. Some of these men may have small testes on clinical examination. The testicular failure may be partial, which means that only a few areas of the testes produce sperm, but this sperm production is not enough for it to be ejaculated. Other men may have complete testicular failure, which means there is no sperm production at all in the entire testes. The only way to differentiate between complete and partial testicular failure is by doing multiple testicular micro-biopsies to sample different areas of the testes and send them for pathological examination.
What if the sperm count is persistently low? Then other tests may be advised, to try to pinpoint what the problem is; and these are described in the next chapter.
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