Outcome of invitro fertilization cycles with preimplantation genetic testing for aneuploidies: lets be honest with one another
Richard J. Paulson, M.D., M.S.
The process is, unfortunately, quite inefficient, and 50% of potential implantations are lost, even by clinics that have experience with PGT-A and are good enough to be chosen for the STAR trial. In an intention-to-treat analysis, the pregnancy rate is not increased. The time to pregnancy is not shortened and there is no decrease in miscarriage rates.
If 50% of potential implantations are lost, under what circumstances can we justify the use of PGT-A? We should begin by letting our patients know what the latest research shows. Informed consent should be fully informed.
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