(Thursday, September 04, 2014)

If your first IVF attempt has failed, you might be wondering when to do the second IVF cycle what to do next. The first thing to do would be to get an honest estimate from your physician, regarding the possibility of success in the second attempt. In cases of problems relating to ovarian stimulation and poor ovarian reserve, we will offer changes in the drug protocol to rectify the problem. If there are problems with the embryo quality, or the egg quality, you could consider using donor eggs. However, you need not immediately opt for such donors, just because the first IVF cycle has failed.

If you are wondering whether you should go in for a second IVF cycle immediately after the first attempt has failed, it is important to be in the right frame of mind. If you are still in a dejected or disappointed mood, you need to give it a few weeks’ time. However, it is not the end of the road for your hopes of bearing a child. After the first cycle has failed, you might start asking yourself what you can do differently in your second IVF cycle. At this point, it is advisable for you and your partner to sit down with your physician and make an analysis of what you learnt from it. It is possible that the ovarian response was not good or the fertilization did not occur or the endometrium was not receptive or some other reasons for the pregnancy failing to take place. Your physicians will advice you about any changes to be made in the second attempt and when to go in for the second attempt.

Regarding the right time as to when to do second IVF, many physicians advise their patients to wait for a few weeks or a month before beginning a new IVF cycle. It is medically possible for going into the next cycle immediately, but you need to take a break in order to get over the disappointment and attain the emotional strength to face the tests and procedures all over again. The time is also essential for your physician to analyze and review your case and the related issues and make modifications to the treatment plan, depending on the analysis and assessment of the previous failed cycle.

For instance, when considering when to do second IVF, doctors might analyze that the ovarian response was not up to the desired level. Hence, he or she can ask you to increase the drug dosage for super-ovulation. In some cases, you might be asked to opt for ICSI or microinjection, in case the fertilization has failed to occur during the first IVF cycle because of sperm dysfunction . In cases of poor embryo quality, you may also be asked to consider embryo adoption.

All IVF programs are not the same , and when you consider where to do your second IVF cycle, it is important to select a good clinic. You can learn more about how to do so at /knowledge-center/articles/negative-beta-hcg-ivf. Malpani Infertility Clinic specializes in treating women who have failed IVF cycles elsewhere. Our team, with skilled physicians and embryologists, helps to maximize chances of success. If the embryos were good and healthy but were not implanted, you can make a second attempt in the same clinic ; but if there were problems with the egg or embryo quality, you will have to consider a better IVF clinic or program, preferably one that has a higher success rate, rather than one which is most convenient or which is the cheapest.


While considering when to do second IVF, it is better to wait for a few weeks after the failed attempt, in order to get over the disappointment; and also to be able to analyze and review the issues causing the failure, so that these can be rectified in the next IVF cycle.

Authored by : Dr Aniruddha Malpani, MD and reviewed by Dr Anjali Malpani.

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